Objective To review the regulation and mechanism of the microRNAs (miRNAs) in the bone and cartilage tissue. Methods Recent l iterature concerning the regulation and mechanism of the miRNAs in the bone and cartilage tissue was extensively reviewed, summarized, and analyzed. Results Recently miRNAs is a hot topic in the bone and cartilage tissue. More and more materials show its important regulatory role in osteogenesis and cartilage growth andregeneration, but the definite mechanisms have not been clear yet. Conclusion The study on miRNAs of bone and cartilage tissue can provide a new access to understanding the degenerative osteoarthritic diseases.
Objective To review the up-to-date development of overseas cl inical study on exercise therapy for patients with knee osteoarthritis. Methods The cl inical researches of exercise therapy for knee osteoarthritis were summarized by reviewing l iterature concerned in recent years. Results Exercise therapy was extensively used in the treatment of knee osteoarthritis not only in hospital but also in community rehabil itation abroad. The main patterns of exercise therapy included muscle strengthening exercise, aerobic exercise and underwater exercise. It was capable of effectively improving patient’s independent l iving abil ity and l ive qual ity, and postproning the time of surgical intervention. But the long-term efficacy of exercise therapy was still under debate. Conclusion Exercise therapy is an effect method to treat knee osteoarthritis.
Objective To analyze the rehabilitation needs and characteristics of patients injured in Jiuzhaigou earthquake, and provide early rehabilitation guidance for the wounded. Methods A total of 42 patients injured in " 8·8” Jiuzhaigou earthquake who were admitted to West China Hospital from August 9th to 16th 2017 for treatment were recruited in this study. Early survey and evaluation were conducted among them by using a self-made questionnaire. Results The top 2 common causes of injury were falling (23 cases, 54.8%) and flying stone (16 cases, 38.1%). The top 2 common injury sites were lower extremity (18 cases, 42.9%) and head (10 cases, 23.8%). Twenty-two cases (52.4%) left the hospital after treatment, 6 (14.3%) went to the Department of Orthopedics, and 6 (14.3%) went to the Department of Neurosurgery. The functional limitations included sensory function in 42 cases (100.0%), mental function in 28 (66.7%), motor function restriction in 24 (57.1%), balance physical limitation in 22 (52.4%), respiratory function in 5 (11.9%), and cardiac function in 1 (2.4%). A total of 37 cases (88.1%) had restricted activities of daily living capacities, mainly including 24 (57.1%) in stair climbing, 24 (57.1%) in walking and 22 (52.4%) in bathing. All the 42 cases needed functional evaluation: 22 (52.4%) needed rehabilitation treatment, and 19 (45.3%) needed rehabilitation aids. Conclusions The injury and function limitation of Jiuzhaigou earthquake victims has its own characteristics. According to the limitation of function, the direction of rehabilitation plan after the earthquake focuses on structural function, psychological function, daily activities and function rehabilitation, so as to bring patients back to the family and society as early as possible.
With the acceleration of the aging in the world and our society, osteoarthritis has become a health concern for patients and health workers. At present, its treatment mainly relies on drug treatment, surgical treatment and rehabilitation. As a safe, non-invasive and simple treatment, pulsed electromagnetic field (PEMF) therapy has been used in clinical treatment of osteoporosis, promoting fracture healing and improving symptoms of osteoarthritis. However, the mechanism of PEMF in the treatment of knee osteoarthritis is still unclear. This paper reviews the effects of PEMF on apoptosis, cytokines, cartilage and subchondral bone in knee osteoarthritis in animal experiments, and the changes of chondrocyte morphology and extracellular matrix in cell experiments, aiming to enable medical workers to better understand the status and development of PEMF in the treatment of knee osteoarthritis in basic experimental researches.
Hypoxia and other factors are related to cognitive impairment. Hyperbaric oxygen therapy can improve tissue oxygen supply to improve brain hypoxia. Based on the basic principle of hyperbaric oxygen therapy, hyperbaric oxygen has been widely used in recent years for cognitive impairment caused by stroke, brain injury, neurodegenerative disease, neuroinflammatory disease and metabolic encephalopathy. This article will review the basic mechanism of hyperbaric oxygen, and summarize and discuss the improvement of hyperbaric oxygen therapy on cognitive and brain diseases, in order to provide relevant reference for clinical treatment.
【摘要】 目的 比较正中神经压迫试验对腕管综合征（carpal tunnel syndrome，CTS）患者正中神经传导速度的影响。 方法 设置CTS组和对照组两个组别，共29例受试者纳入研究。CTS组为14例CTS患者，对照组为15例健康受试者。神经传导速度测定包括正中神经和尺神经的感觉传导末端潜伏期（distal sensory latency，DSL）、感觉神经动作电位（sensory nerve action potential， SNAP）、跨腕关节感觉传导速度（sensory conduction velocity，SCV）、运动传导末端潜伏期（distal motor latency，DML）及复合肌肉动作电位（compound muscle action potential，CMAP）。先测感觉传导，再测运动传导。正中神经压迫试验5 min后再次测量上述指标。 结果 正中神经压迫试验前后电生理检查考虑诊断CTS分别为22侧和24侧。压迫正中神经后，CTS组正中神经DSL较压迫前显著延长（Plt;0.05）。CTS组尺神经和对照组正中神经及尺神经的各参数在压迫前后均无显著改变（Pgt;0.05）。与对照组相比，在压迫试验前后CTS组的正中神经DSL和DML均明显延长（Plt;0.05），尺神经DSL和DML均无显著改变（Pgt;0.05）。 结论 正中神经压迫试验5 min能使CTS患者正中神经的感觉传导末端潜伏时明显延长，有助于提高神经传导测定对早期CTS的诊断率。【Abstract】 Objective To determine the effect of median nerve compression on median nerve conduction speed in patients with carpal tunnel syndrome (CTS). Methods In this case-control study, 29 subjects were enrolled. CTS group included 14 patients (22 hands) with CTS confirmed by electrodiagnostic studies, while the control group included 15 healthy subjects (30 hands). The across wrist nerve conduction of median and ulnar nerve was measured when the wrist was in neutral position. Measured parameters included distal sensory latency (DSL), sensory nerve action potential (SNAP), sensory conduction velocity (SCV), distal motor latency (DML) and compound muscle action potential (CMAP). Sensory nerve conductions were tested first, and then the motor nerve conduction. The patients were asked to perform the median nerve compression test by flexing elbows, pronating forearm and pushing the dorsal surfaces of both hands together into maximum wrist flexion for 5 minutes. Then the above parameters were measured again. Results By electrodiagnostic studies, 22 hands and 24 bands were diagnosed with CTS before and after the median nerve compression test, respectively. After the compression test, the median nerve DSL were significantly prolonged in CTS group (Plt;0.05) but no significant differences were found in the median nerve DML (Pgt;0.05). The parameters of ulnar nerve in group CTS and median nerve and ulnar nerve in control group failed to show any significant change (Pgt;0.05). The CTS group had longer median nerve DSL and DML than the control groups (Plt;0.05), but the differences in ulnar nerve DSL and DML were not significantly between the two groups. Conclusion A 5-minute median nerve compression test may make the median nerve DSL prolonged and may be a helpful diagnosis of early CTS.
Objective To investigate the changes of lumbar bone histomorphometry after exposure to low frequency pulsed electromagnetic fields (PEMFs), and to further understand the effect of PEMFs on osteoporosis (OP) in ovariectomizedOP rats. Methods Sixty-six 3-month-old Sprague Dawley rats were randomly divided into 4 groups: group A(n=12), groupB (n=12), group C (n=12), and group D (n=30). In group A, the ovaries were not resected as sham-ovariectomy; in groupsB, C, and D, the ovaries were resected. At 12 weeks after ovariectomy, the rats were exposed to PEMFs at 8 Hz, 3.8 mT, and 40 minutes/ day for 30 days in group B; the rats were administered with premarin [0.065 mg/(kg·d) by gavage for 30 days] in group C; in group D, the rats were housed as ovariectomy control. The hair and activity of rats were observed; the levels of serum estradiol were determined. At 30 days after intervention, all rats were sacrificed to harvest the L4 vertebrae for bone histomorphometry. Results General observation showed hair loss and decreased activity in group D, and no abnormal appearances in groups A, B, and C. The level of serum estradiol in group A was significantly higher than that in group D [(54.93 ± 23.52) pg/mL vs. (31.99 ± 23.45) pg/mL] (t=2.345, P=0.029). Histological observation showed thinness of sclerotin, bigger medullary cavity, and sparse and thinner bone trabecula in group D; uniform bone trabecula with no breakage in groups A, B, and C at 30 days after intervention. The ratio of trabecular bone area in group B was significantly higher than that in group D (P lt; 0.05); it was higher than that in groups A and C, showing no significant difference (P gt; 0.05). The trabecular thickness in group B was significantly higher than that in group D (P lt; 0.05), but it was lower than that in groups A and C, showing no significant difference (P gt; 0.05). The trabecular number in group B was significantly lower than that in group D (P lt; 0.05), but it was higher than that in groups A and C, showing no significant difference (P gt; 0.05). The trabecular separation in group B was higher than that in group D and lower than that in groups A and C, showing no significant difference (P gt; 0.05). Conclusion PEMFs at 8 Hz and 3.8 mT can significantly improve the character of bone microstructure in ovariectomized OP rats, increase the ratio of bone trabecular area and trabecular thickness, and decrease the trabecular number.
目的：探讨5·12汶川地震致脊髓损伤患者神经源膀胱的康复治疗方法。方法：通过对35例脊髓损伤患者神经源膀胱康复治疗的总结回顾，观察采用制定饮水计划，间歇性导尿，药物治疗，膀胱功能训练，手术治疗等方法治疗神经源膀胱的疗效。结果：经过综合治疗，35例患者的神经源膀胱都得到了不同程度的改善。结论：地震致脊髓损伤发生率高，而神经源膀胱是其重大并发症之一，危害患者生命，重建脊髓损伤后患者的膀胱功能对于提高截瘫患者的生活质量，降低死亡率具有十分重要的意义。
通过与首都医科大学、南京医科大学、中山医科大学、四川大学的康复医学研究人员2000年1月至2008年3月止发表在康复医学主要五种杂志上的期刊论文,从论文年代分布、领域论文分布、核心期刊发文率、基金资助研究情况、主题分布情况等方面进行了全面的统计分析,比较客观地揭示和描述了新世纪初四川大学华西医院康复医学中心康复医学研究与发展的基本状况,并提出发展的可能策略。
Spinal cord injury (SCI) patients are high-risk groups of hospitalized patients with venous thrombosis embolism (VTE). VTE is one of the important causes of inpatients’ unexpected death and perioperative accidental death, so SCI patients with VTE deserve special attention. In recent years, the risk factors, epidemiological characteristics, pathogenesis, and prevention of VTE have been further understood. We also have a more comprehensive and in-depth understanding of the treatment of venous thrombosis, including general prevention, drug, interventional surgery, rehabilitation, etc. Non-invasive examination, new therapeutic technologies, and new oral anticoagulant drugs have also greatly promoted the prevention and treatment of VTE. Meanwhile, prevention system of VTE has been developed from single subject work gradually to the multidisciplinary, multiple grades and doctor-patient cooperation mode, is no longer just dominated by clinical departments, but dominated by hospitals and even higher level department, and a more scientific and effective management mode has being under construction, all of these will further optimize the clinical prevention and treatment of venous thrombosis.